Ocular tuberculosis (TB) is difficult to manage due to heterogeneous presentations, mixed ocular tissue involvement, lack of international consensus on the use of investigations for diagnosis, and lack of international consensus on the approach to management. As a result, diagnosis and treatment often directed by the attending specialist trained uveitis experts, at times in collaboration with infectious disease and/or respiratory physicians.The Collaborative Ocular TB Study (COTS) group in collaboration with International ocular inflammation Society (IOIS), International uveitis study group (IUSG) and The Foster Ocular Immunology Society (FOIS) aims to set up the guidelines for diagnosis and management of ocular TB.

COTS-1

A multinational retrospective cohort study where the information was obtained from records of events that have occurred in the past, primarily medical records.

This real life large database of patients will provide reproducible and reliable information regarding the clinical signs that may be indicative of ocular TB, whether or not the use of anti-tubercular therapy (ATT) helps in reducing the recurrence, and the role of concomitant systemic corticosteroids in patients with ocular TB.

COTS-Con

A survey-based investigation designed to consolidate the expertise of international uveitis experts on the approach to the management of TB Uveitis.

This survey uses a tiered approach to pool the expertise of uveitis experts to generate a classification for the strength of clinical suspicion associated with individual clinical findings on history taking or examination; with regards to whether these phenotypes warrant treatment with anti-tubercular therapy (ATT).

COTS Registry

A centralized database of a large cohort of patients who have received the diagnosis of ocular TB.

The primary aim of this study is to determine the sensitivity and specificity of different clinical signs (using both clinical description and images) suggestive of ocular TB in a prospective longitudinal multi-centre study of different ethnicities and to find out the sensitivity and specificity of different diagnostic tests in the diagnosis of ocular tuberculosis.